Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability

The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. We introduce a coupled Bayesian regression approach—eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies c...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Avinash, Morley, Michael, Moravec, Christine S., Tang, W. H. W., Hakonarson, Hakon, Margulies, Kenneth B., Cappola, Thomas P., Jensen, Shane, Hannenhalli, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633824/
https://www.ncbi.nlm.nih.gov/pubmed/26456756
http://dx.doi.org/10.1038/ncomms9555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633824/
https://www.ncbi.nlm.nih.gov/pubmed/26456756
http://dx.doi.org/10.1038/ncomms9555

Ejemplares similares