Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

Regulatory T-cells induced via IL-2 and TGFβ in vitro (iTreg) suppress immune cells and are potential therapeutics during autoimmunity. However, several reports described their re-differentiation into pathogenic cells in vivo and loss of their key functional transcription factor (TF) FOXP3 after T-c...

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Detalles Bibliográficos
Autores principales: Bothur, Evita, Raifer, Hartmann, Haftmann, Claudia, Stittrich, Anna-Barbara, Brüstle, Anne, Brenner, Dirk, Bollig, Nadine, Bieringer, Maria, Kang, Chol-Ho, Reinhard, Katharina, Camara, Bärbel, Huber, Magdalena, Visekruna, Alexander, Steinhoff, Ulrich, Repenning, Antje, Bauer, Uta-Maria, Sexl, Veronika, Radbruch, Andreas, Sparwasser, Tim, Mashreghi, Mir-Farzin, Wah Mak, Tak, Lohoff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633965/
https://www.ncbi.nlm.nih.gov/pubmed/26815406
http://dx.doi.org/10.1038/ncomms9576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633965/
https://www.ncbi.nlm.nih.gov/pubmed/26815406
http://dx.doi.org/10.1038/ncomms9576

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