Notch signal strength controls cell fate in the haemogenic endothelium

Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the haemogenic endothelium/HSC on Jag1-mediated Notch1 signalling. How Notch1 dis...

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Detalles Bibliográficos
Autores principales: Gama-Norton, Leonor, Ferrando, Eva, Ruiz-Herguido, Cristina, Liu, Zenhy, Guiu, Jordi, Islam, Abul B. M. M. K., Lee, Sung-Uk, Yan, Minhong, Guidos, Cynthia J., López-Bigas, Nuria, Maeda, Takahiro, Espinosa, Lluis, Kopan, Raphael, Bigas, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634136/
https://www.ncbi.nlm.nih.gov/pubmed/26465397
http://dx.doi.org/10.1038/ncomms9510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634136/
https://www.ncbi.nlm.nih.gov/pubmed/26465397
http://dx.doi.org/10.1038/ncomms9510

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