Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis

Please cite this paper as: Savy et al. (2012) Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12036. Objective  Influenza causes severe morbidity and mortality. This systematic review aimed to ass...

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Autores principales: Savy, Vilma, Ciapponi, Agustín, Bardach, Ariel, Glujovsky, Demián, Aruj, Patricia, Mazzoni, Agustina, Gibbons, Luz, Ortega‐Barría, Eduardo, Colindres, Rómulo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634294/
https://www.ncbi.nlm.nih.gov/pubmed/23210504
http://dx.doi.org/10.1111/irv.12036
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author Savy, Vilma
Ciapponi, Agustín
Bardach, Ariel
Glujovsky, Demián
Aruj, Patricia
Mazzoni, Agustina
Gibbons, Luz
Ortega‐Barría, Eduardo
Colindres, Rómulo E.
author_facet Savy, Vilma
Ciapponi, Agustín
Bardach, Ariel
Glujovsky, Demián
Aruj, Patricia
Mazzoni, Agustina
Gibbons, Luz
Ortega‐Barría, Eduardo
Colindres, Rómulo E.
author_sort Savy, Vilma
collection PubMed
description Please cite this paper as: Savy et al. (2012) Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12036. Objective  Influenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean. Design  Meta‐analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta‐analyses. Setting  A literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts. Sample  We identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET. Main outcome measures  Incidence, percentage of influenza specimens out of the total received by influenza centers and resource‐use outcomes. Results  A total of 483 130 specimens of patients with influenza were analyzed. Meta‐analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza‐like illness per 100 000 persons‐years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza‐like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory‐confirmed influenza case. Conclusions  Our data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine‐uptake rate has been low in this region. Population‐based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making.
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spelling pubmed-46342942015-12-01 Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis Savy, Vilma Ciapponi, Agustín Bardach, Ariel Glujovsky, Demián Aruj, Patricia Mazzoni, Agustina Gibbons, Luz Ortega‐Barría, Eduardo Colindres, Rómulo E. Influenza Other Respir Viruses Part 2 Epidemiology and Impact of Respiratory Virus Infections Please cite this paper as: Savy et al. (2012) Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12036. Objective  Influenza causes severe morbidity and mortality. This systematic review aimed to assess the incidence, etiology, and resource usage for influenza in Latin America and the Caribbean. Design  Meta‐analytic systematic review. Arcsine transformations and DerSimonian Laird random effects model were used for meta‐analyses. Setting  A literature search from 1980 to 2008 in MEDLINE, Cochrane Library, EMBASE, LILACS, Ministries of Health, PAHO, proceedings, reference lists, and consulting experts. Sample  We identified 1092 references, of which 31 were finally included, in addition to influenza surveillance reports. We also used information from the 10 reports from the collaborative group for epidemiological surveillance of influenza and other respiratory virus (GROG), and information retrieved from the WHO global flu database FLUNET. Main outcome measures  Incidence, percentage of influenza specimens out of the total received by influenza centers and resource‐use outcomes. Results  A total of 483 130 specimens of patients with influenza were analyzed. Meta‐analysis showed an annual rate of 36 080 (95%CI 28 550 43 610) influenza‐like illness per 100 000 persons‐years. The percentage of influenza out of total specimens received by influenza centers ranged between 4.66% and 15.42%, with type A the most prevalent, and A subtype H3 predominating. The mean length of stay at hospital due to influenza ranged between 5.8 12.9 days, total workdays lost due to influenza‐like illnesses were 17 150 days, and the mean direct cost of hospitalization was US$575 per laboratory‐confirmed influenza case. Conclusions  Our data show that seasonal influenza imposes a high morbidity and economic burden to the region. However, the vaccine‐uptake rate has been low in this region. Population‐based cohort studies are required to improve the knowledge about incidence and resource utilization, which would inform healthcare authorities for decision making. Blackwell Publishing Ltd 2012-12-05 2013-11 /pmc/articles/PMC4634294/ /pubmed/23210504 http://dx.doi.org/10.1111/irv.12036 Text en © 2012 John Wiley & Sons Ltd
spellingShingle Part 2 Epidemiology and Impact of Respiratory Virus Infections
Savy, Vilma
Ciapponi, Agustín
Bardach, Ariel
Glujovsky, Demián
Aruj, Patricia
Mazzoni, Agustina
Gibbons, Luz
Ortega‐Barría, Eduardo
Colindres, Rómulo E.
Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title_full Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title_fullStr Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title_full_unstemmed Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title_short Burden of influenza in Latin America and the Caribbean: a systematic review and meta‐analysis
title_sort burden of influenza in latin america and the caribbean: a systematic review and meta‐analysis
topic Part 2 Epidemiology and Impact of Respiratory Virus Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634294/
https://www.ncbi.nlm.nih.gov/pubmed/23210504
http://dx.doi.org/10.1111/irv.12036
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