Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

Autosomal recessively inherited glucocerebrosidase 1 (GBA1) mutations cause the lysosomal storage disorder Gaucher's disease (GD). Heterozygous GBA1 mutations (GBA1(+/−)) are the most common risk factor for Parkinson's disease (PD). Previous studies typically focused on the interaction bet...

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Detalles Bibliográficos
Autores principales: Keatinge, Marcus, Bui, Hai, Menke, Aswin, Chen, Yu-Chia, Sokol, Anna M., Bai, Qing, Ellett, Felix, Da Costa, Marc, Burke, Derek, Gegg, Matthew, Trollope, Lisa, Payne, Thomas, McTighe, Aimee, Mortiboys, Heather, de Jager, Sarah, Nuthall, Hugh, Kuo, Ming-Shang, Fleming, Angeleen, Schapira, Anthony H.V., Renshaw, Stephen A., Highley, J. Robin, Chacinska, Agnieszka, Panula, Pertti, Burton, Edward A., O'Neill, Michael J., Bandmann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634372/
https://www.ncbi.nlm.nih.gov/pubmed/26376862
http://dx.doi.org/10.1093/hmg/ddv369

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634372/
https://www.ncbi.nlm.nih.gov/pubmed/26376862
http://dx.doi.org/10.1093/hmg/ddv369

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