Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

BACKGROUND: Dendritic simplification, a key feature of the neurodegenerative triad of Alzheimer’s disease (AD) in addition to spine changes and neuron loss, occurs in a region-specific manner. However, it is unknown how changes in dendritic complexity are mediated and how they relate to spine change...

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Detalles Bibliográficos
Autores principales: Golovyashkina, Nataliya, Penazzi, Lorène, Ballatore, Carlo, Smith, Amos B., Bakota, Lidia, Brandt, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634596/
https://www.ncbi.nlm.nih.gov/pubmed/26541821
http://dx.doi.org/10.1186/s13024-015-0049-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634596/
https://www.ncbi.nlm.nih.gov/pubmed/26541821
http://dx.doi.org/10.1186/s13024-015-0049-0

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