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Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet

Diabetes is a chronic inflammatory disease that carries a high risk of cardiovascular disease. However, the pathophysiological link between these disorders is not well known. We hypothesize that TLR4 signaling mediates high fat diet (HFD)-induced peripheral and cardiac glucose metabolic derangements...

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Detalles Bibliográficos
Autores principales: Jackson, Ellen E., Rendina-Ruedy, Elisabeth, Smith, Brenda J., Lacombe, Veronique A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634760/
https://www.ncbi.nlm.nih.gov/pubmed/26539824
http://dx.doi.org/10.1371/journal.pone.0142077