Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain

BACKGROUND: Subcutaneous methylnaltrexone is efficacious and well tolerated for opioid-induced constipation (OIC) but may theoretically disrupt opioid-mediated analgesia. METHODS: Opioid use, pain intensity, and opioid withdrawal (Objective Opioid Withdrawal Scale [OOWS] and Subjective Opiate Withdr...

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Detalles Bibliográficos
Autores principales: Webster, Lynn R, Brenner, Darren M, Barrett, Andrew C, Paterson, Craig, Bortey, Enoch, Forbes, William P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634837/
https://www.ncbi.nlm.nih.gov/pubmed/26586963
http://dx.doi.org/10.2147/JPR.S88203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634837/
https://www.ncbi.nlm.nih.gov/pubmed/26586963
http://dx.doi.org/10.2147/JPR.S88203

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