Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

BACKGROUND: Antibodies to citrullinated proteins (ACPA) occur years before RA diagnosis. Porphyromonas gingivalis expresses its own peptidylarginine deiminase (PPAD), and is a proposed aetiological factor for the ACPA response. Smoking is a risk factor for both ACPA-positive RA and periodontitis. We...

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Detalles Bibliográficos
Autores principales: Fisher, Benjamin A., Cartwright, Alison J., Quirke, Anne-Marie, de Pablo, Paola, Romaguera, Dora, Panico, Salvatore, Mattiello, Amalia, Gavrila, Diana, Navarro, Carmen, Sacerdote, Carlotta, Vineis, Paolo, Tumino, Rosario, Lappin, David F., Apazidou, Danae, Culshaw, Shauna, Potempa, Jan, Michaud, Dominique S., Riboli, Elio, Venables, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634856/
https://www.ncbi.nlm.nih.gov/pubmed/26537917
http://dx.doi.org/10.1186/s12891-015-0792-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634856/
https://www.ncbi.nlm.nih.gov/pubmed/26537917
http://dx.doi.org/10.1186/s12891-015-0792-y

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