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Hoechst 33342 Is a Hidden “Janus” amongst Substrates for the Multidrug Efflux Pump LmrP

Multidrug transporters mediate the active extrusion of antibiotics and toxic ions from the cell. This reaction is thought to be based on a switch of the transporter between two conformational states, one in which the interior substrate binding cavity is available for substrate binding at the inside...

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Detalles Bibliográficos
Autores principales: Neuberger, Arthur, van Veen, Hendrik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634932/
https://www.ncbi.nlm.nih.gov/pubmed/26540112
http://dx.doi.org/10.1371/journal.pone.0141991