The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

The perforant pathway projection from layer II of the entorhinal cortex to the hippocampal dentate gyrus is especially important for long-term memory formation, and is preferentially vulnerable to developing a degenerative tauopathy early in Alzheimer’s disease (AD) that may spread over time trans-s...

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Detalles Bibliográficos
Autores principales: Siman, Robert, Cocca, Ryan, Dong, Yina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634963/
https://www.ncbi.nlm.nih.gov/pubmed/26540269
http://dx.doi.org/10.1371/journal.pone.0142340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634963/
https://www.ncbi.nlm.nih.gov/pubmed/26540269
http://dx.doi.org/10.1371/journal.pone.0142340

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