Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data

BACKGROUND: The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, time-co...

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Detalles Bibliográficos
Autores principales: Pizzo, Fabiola, Gadaleta, Domenico, Lombardo, Anna, Nicolotti, Orazio, Benfenati, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635184/
https://www.ncbi.nlm.nih.gov/pubmed/26550029
http://dx.doi.org/10.1186/s13065-015-0139-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635184/
https://www.ncbi.nlm.nih.gov/pubmed/26550029
http://dx.doi.org/10.1186/s13065-015-0139-7

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