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Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data
BACKGROUND: The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, time-co...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635184/ https://www.ncbi.nlm.nih.gov/pubmed/26550029 http://dx.doi.org/10.1186/s13065-015-0139-7 |