Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation

Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes, making...

Descripción completa

Detalles Bibliográficos
Autores principales: Frej, Cecilia, Andersson, Anders, Larsson, Benny, Guo, Li Jun, Norström, Eva, Happonen, Kaisa E., Dahlbäck, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635185/
https://www.ncbi.nlm.nih.gov/pubmed/26377937
http://dx.doi.org/10.1007/s00216-015-9008-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635185/
https://www.ncbi.nlm.nih.gov/pubmed/26377937
http://dx.doi.org/10.1007/s00216-015-9008-4

Ejemplares similares