Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

Although the therapeutic benefit of proteasome inhibition in multiple myeloma remains unchallenged, drug resistance inevitably emerges through mechanisms that remain elusive. Bortezomib provokes unwanted protein accumulation and the endoplasmic reticulum stress to activate the unfolded protein respo...

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Detalles Bibliográficos
Autores principales: Jagannathan, S, Abdel-Malek, M A Y, Malek, E, Vad, N, Latif, T, Anderson, K C, Driscoll, J J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635337/
https://www.ncbi.nlm.nih.gov/pubmed/26108695
http://dx.doi.org/10.1038/leu.2015.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635337/
https://www.ncbi.nlm.nih.gov/pubmed/26108695
http://dx.doi.org/10.1038/leu.2015.157

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