Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages

Here we report a novel regulatory mechanism for autophagy-mediated degradation of Mycobacterium tuberculosis (Mtb) and specific strategy exploited by the virulent Mtb to evade it. We show while both avirulent (H37Ra) and virulent (H37Rv) mycobacteria could readily localize to autophagosomes, their m...

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Detalles Bibliográficos
Autores principales: Chandra, Pallavi, Ghanwat, Swapnil, Matta, Sumit Kumar, Yadav, Swati Seth, Mehta, Mansi, Siddiqui, Zaved, Singh, Amit, Kumar, Dhiraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635374/
https://www.ncbi.nlm.nih.gov/pubmed/26541268
http://dx.doi.org/10.1038/srep16320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635374/
https://www.ncbi.nlm.nih.gov/pubmed/26541268
http://dx.doi.org/10.1038/srep16320

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