Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Inhibitor studies with isolated mitochondria demonstrated that complex I (CI) and III (CIII) of the electron transport chain (ETC) can act as relevant sources of mitochondrial reactive oxygen species (ROS). Here we studied ROS generation and oxidative stress induction during chronic (24 h) inhibitio...

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Detalles Bibliográficos
Autores principales: Forkink, Marleen, Basit, Farhan, Teixeira, José, Swarts, Herman G., Koopman, Werner J.H., Willems, Peter H.G.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635408/
https://www.ncbi.nlm.nih.gov/pubmed/26516986
http://dx.doi.org/10.1016/j.redox.2015.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635408/
https://www.ncbi.nlm.nih.gov/pubmed/26516986
http://dx.doi.org/10.1016/j.redox.2015.09.003

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