Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29

The lipopeptides ramoplanin from Actinoplanes sp. ATCC 33076 and enduracidin produced by Streptomyces fungicidicus are effective antibiotics against a number of drug-resistant Gram-positive pathogens. While these two antibiotics share a similar cyclic peptide structure, comprising 17 amino acids wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Ming-Cheng, Styles, Matthew Q., Law, Brian J. C., Struck, Anna-Winona, Nunns, Laura, Micklefield, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2015
Materias:
Standard
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635501/
https://www.ncbi.nlm.nih.gov/pubmed/25878261
http://dx.doi.org/10.1099/mic.0.000095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635501/
https://www.ncbi.nlm.nih.gov/pubmed/25878261
http://dx.doi.org/10.1099/mic.0.000095

Ejemplares similares