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Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29

The lipopeptides ramoplanin from Actinoplanes sp. ATCC 33076 and enduracidin produced by Streptomyces fungicidicus are effective antibiotics against a number of drug-resistant Gram-positive pathogens. While these two antibiotics share a similar cyclic peptide structure, comprising 17 amino acids wit...

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Detalles Bibliográficos
Autores principales:	Wu, Ming-Cheng, Styles, Matthew Q., Law, Brian J. C., Struck, Anna-Winona, Nunns, Laura, Micklefield, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for General Microbiology 2015
Materias:	Standard
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635501/ https://www.ncbi.nlm.nih.gov/pubmed/25878261 http://dx.doi.org/10.1099/mic.0.000095

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