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Regulation of multispanning membrane protein topology via post-translational annealing

The canonical mechanism for multispanning membrane protein topogenesis suggests that protein topology is established during cotranslational membrane integration. However, this mechanism is inconsistent with the behavior of EmrE, a dual-topology protein for which the mutation of positively charged lo...

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Detalles Bibliográficos
Autores principales: Van Lehn, Reid C, Zhang, Bin, Miller, Thomas F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635508/
https://www.ncbi.nlm.nih.gov/pubmed/26408961
http://dx.doi.org/10.7554/eLife.08697