Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges...

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Detalles Bibliográficos
Autores principales: Hatfield, Stephen M, Sitkovsky, Michail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/
https://www.ncbi.nlm.nih.gov/pubmed/26587328
http://dx.doi.org/10.1080/2162402X.2015.1052934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/
https://www.ncbi.nlm.nih.gov/pubmed/26587328
http://dx.doi.org/10.1080/2162402X.2015.1052934

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