Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators

Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges...

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Detalles Bibliográficos
Autores principales: Hatfield, Stephen M, Sitkovsky, Michail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/
https://www.ncbi.nlm.nih.gov/pubmed/26587328
http://dx.doi.org/10.1080/2162402X.2015.1052934
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author Hatfield, Stephen M
Sitkovsky, Michail
author_facet Hatfield, Stephen M
Sitkovsky, Michail
author_sort Hatfield, Stephen M
collection PubMed
description Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
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spelling pubmed-46358832016-02-03 Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators Hatfield, Stephen M Sitkovsky, Michail Oncoimmunology Author's View Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies. Taylor & Francis 2015-06-01 /pmc/articles/PMC4635883/ /pubmed/26587328 http://dx.doi.org/10.1080/2162402X.2015.1052934 Text en © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Hatfield, Stephen M
Sitkovsky, Michail
Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title_full Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title_fullStr Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title_full_unstemmed Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title_short Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
title_sort oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/
https://www.ncbi.nlm.nih.gov/pubmed/26587328
http://dx.doi.org/10.1080/2162402X.2015.1052934
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