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Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635883/ https://www.ncbi.nlm.nih.gov/pubmed/26587328 http://dx.doi.org/10.1080/2162402X.2015.1052934 |