Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D

Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetra...

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Detalles Bibliográficos
Autores principales: Evans, Elizabeth E, Paris, Mark, Smith, Ernest S, Zauderer, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635900/
https://www.ncbi.nlm.nih.gov/pubmed/26587332
http://dx.doi.org/10.1080/2162402X.2015.1054599
Descripción
Sumario:Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.

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