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Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors?
Program death receptor-1 (PD-1) is upregulated in many tumors and in tumor microenvironment, and PD-1 blockade has led to remarkable immune-based anti-tumor responses in across many tumor types. Pembrolizumab, an anti-programmed death 1 checkpoint inhibitor, resulted in a high rate of immune respons...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636069/ https://www.ncbi.nlm.nih.gov/pubmed/26542241 http://dx.doi.org/10.1186/s13045-015-0222-5 |