Regulated CRISPR Modules Exploit a Dual Defense Strategy of Restriction and Abortive Infection in a Model of Prokaryote-Phage Coevolution

CRISPRs offer adaptive immunity in prokaryotes by acquiring genomic fragments from infecting phage and subsequently exploiting them for phage restriction via an RNAi-like mechanism. Here, we develop and analyze a dynamical model of CRISPR-mediated prokaryote-phage coevolution that incorporates class...

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Detalles Bibliográficos
Autores principales: Kumar, M. Senthil, Plotkin, Joshua B., Hannenhalli, Sridhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636164/
https://www.ncbi.nlm.nih.gov/pubmed/26544847
http://dx.doi.org/10.1371/journal.pcbi.1004603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636164/
https://www.ncbi.nlm.nih.gov/pubmed/26544847
http://dx.doi.org/10.1371/journal.pcbi.1004603

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