Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice

Valosin-containing protein (VCP) is a homohexameric ATPase involved in a multitude cellular processes and it was recently shown that VCP is trimethylated at lysine 315 by the VCP lysine methyltransferase (VCPKMT). Here, we generated and validated a constitutive knockout mouse by targeting exon 1–4 o...

Descripción completa

Detalles Bibliográficos
Autores principales: Fusser, Markus, Kernstock, Stefan, Aileni, Vinay Kumar, Egge-Jacobsen, Wolfgang, Falnes, Pål Ø., Klungland, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636187/
https://www.ncbi.nlm.nih.gov/pubmed/26544960
http://dx.doi.org/10.1371/journal.pone.0141472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636187/
https://www.ncbi.nlm.nih.gov/pubmed/26544960
http://dx.doi.org/10.1371/journal.pone.0141472

Ejemplares similares