Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier

The impermeability of the adult blood-brain barrier (BBB) to lysosomal enzymes impedes the ability to treat the central nervous system manifestations of lysosomal storage diseases. Here, we found that simultaneous stimulation of the alpha1 and alpha2 adrenoreceptor restores in adult mice the high ra...

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Detalles Bibliográficos
Autores principales: Urayama, Akihiko, Dohgu, Shinya, Robinson, Sandra M., Sly, William S., Grubb, Jeffery H., Banks, William A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636227/
https://www.ncbi.nlm.nih.gov/pubmed/26545208
http://dx.doi.org/10.1371/journal.pone.0142347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636227/
https://www.ncbi.nlm.nih.gov/pubmed/26545208
http://dx.doi.org/10.1371/journal.pone.0142347

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