Cargando…
Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier
The impermeability of the adult blood-brain barrier (BBB) to lysosomal enzymes impedes the ability to treat the central nervous system manifestations of lysosomal storage diseases. Here, we found that simultaneous stimulation of the alpha1 and alpha2 adrenoreceptor restores in adult mice the high ra...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636227/ https://www.ncbi.nlm.nih.gov/pubmed/26545208 http://dx.doi.org/10.1371/journal.pone.0142347 |