A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

G protein-gated K(+) channels (GIRK; Kir3), activated by Gβγ subunits derived from G(i/o) proteins, regulate heartbeat and neuronal excitability and plasticity. Both neurotransmitter-evoked (I(evoked)) and neurotransmitter-independent basal (I(basal)) GIRK activities are physiologically important, b...

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Detalles Bibliográficos
Autores principales: Yakubovich, Daniel, Berlin, Shai, Kahanovitch, Uri, Rubinstein, Moran, Farhy-Tselnicker, Isabella, Styr, Boaz, Keren-Raifman, Tal, Dessauer, Carmen W., Dascal, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636287/
https://www.ncbi.nlm.nih.gov/pubmed/26544551
http://dx.doi.org/10.1371/journal.pcbi.1004598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636287/
https://www.ncbi.nlm.nih.gov/pubmed/26544551
http://dx.doi.org/10.1371/journal.pcbi.1004598

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