Cargando…

Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egress

Members of the family of calcium dependent protein kinases (CDPK’s) are abundant in certain pathogenic parasites and absent in mammalian cells making them strong drug target candidates. In the obligate intracellular parasite Toxoplasma gondii TgCDPK3 is important for calcium dependent egress from th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gaji, Rajshekhar Y., Johnson, Derrick E., Treeck, Moritz, Wang, Mu, Hudmon, Andy, Arrizabalaga, Gustavo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636360/ https://www.ncbi.nlm.nih.gov/pubmed/26544049 http://dx.doi.org/10.1371/journal.ppat.1005268

Ejemplares similares

TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
por: McCoy, James M., et al.
Publicado: (2012)

Correction: TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
por: McCoy, James M., et al.
Publicado: (2013)

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii
por: Bansal, Priyanka, et al.
Publicado: (2021)

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii
por: Gharibi, Zahra, et al.
Publicado: (2023)

Immune responses and protection after DNA vaccination against Toxoplasma gondii calcium-dependent protein kinase 2 (TgCDPK2)
por: Chen, Kai, et al.
Publicado: (2017)

The Calcium-Dependent Protein Kinase 3 of Toxoplasma Influences Basal Calcium Levels and Functions beyond Egress as Revealed by Quantitative Phosphoproteome Analysis
por: Treeck, Moritz, et al.
Publicado: (2014)

Protective efficacy of Toxoplasma gondiicalcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice
por: Chen, Jia, et al.
Publicado: (2014)

Immunization With a DNA Vaccine Cocktail Encoding TgPF, TgROP16, TgROP18, TgMIC6, and TgCDPK3 Genes Protects Mice Against Chronic Toxoplasmosis
por: Zhang, Nian-Zhang, et al.
Publicado: (2018)

A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress
por: Nofal, Stephanie D., et al.
Publicado: (2022)

TgTKL4 Is a Novel Kinase That Plays an Important Role in Toxoplasma Morphology and Fitness
por: Montano, Hilary, et al.
Publicado: (2023)

TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis
por: Varberg, Joseph M., et al.
Publicado: (2018)

CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility
por: Shortt, Emily, et al.
Publicado: (2023)

A Window to Toxoplasma gondii Egress
por: Caldas, Lucio Ayres, et al.
Publicado: (2018)

Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity
por: Roiko, Marijo S., et al.
Publicado: (2014)

Toxoplasma gondii CDPK3 Controls the Intracellular Proliferation of Parasites in Macrophages
por: Wu, Minmin, et al.
Publicado: (2022)

A Forward Genetic Screen Reveals that Calcium-dependent Protein Kinase 3 Regulates Egress in Toxoplasma
por: Garrison, Erin, et al.
Publicado: (2012)

A Novel High Throughput Invasion Screen Identifies Host Actin Regulators Required for Efficient Cell Entry by Toxoplasma gondii
por: Gaji, Rajshekhar Y., et al.
Publicado: (2013)

Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress
por: Schultz, Aric J., et al.
Publicado: (2018)

TgATAT-Mediated α-Tubulin Acetylation Is Required for Division of the Protozoan Parasite Toxoplasma gondii
por: Varberg, Joseph M., et al.
Publicado: (2016)

Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress
por: Dubois, David J., et al.
Publicado: (2023)

The Dually Localized EF-Hand Domain-Containing Protein TgEFP1 Regulates the Lytic Cycle of Toxoplasma gondii
por: Dave, Noopur, et al.
Publicado: (2022)

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
por: Chan, Alex W, et al.
Publicado: (2023)

Actin and an unconventional myosin motor, TgMyoF, control the organization and dynamics of the endomembrane network in Toxoplasma gondii
por: Carmeille, Romain, et al.
Publicado: (2021)

Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma
por: Chan, Alex W, et al.
Publicado: (2023)

A plasma membrane localized protein phosphatase in Toxoplasma gondii, PPM5C, regulates attachment to host cells
por: Yang, Chunlin, et al.
Publicado: (2019)

Bioinformatics analysis of calcium-dependent protein kinase 4 (CDPK4) as Toxoplasma gondii vaccine target
por: Foroutan, Masoud, et al.
Publicado: (2021)

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
por: Huang, Wenlin, et al.
Publicado: (2015)

Disruption of TgPHIL1 Alters Specific Parameters of Toxoplasma gondii Motility Measured in a Quantitative, Three-Dimensional Live Motility Assay
por: Leung, Jacqueline M., et al.
Publicado: (2014)

Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells
por: Huynh, My-Hang, et al.
Publicado: (2021)

Apically-located P4-ATPase1-Lem1 complex internalizes phosphatidylserine and regulates motility-dependent invasion and egress in Toxoplasma gondii
por: Chen, Kai, et al.
Publicado: (2023)

Immunoinformatic Analysis of Calcium-Dependent Protein Kinase 7 (CDPK7) Showed Potential Targets for Toxoplasma gondii Vaccine
por: Taghipour, Ali, et al.
Publicado: (2021)

Live-attenuated ME49Δcdpk3 strain of Toxoplasma gondii protects against acute and chronic toxoplasmosis
por: Wu, Minmin, et al.
Publicado: (2022)

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
por: Liu, Min, et al.
Publicado: (2019)

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress
por: Fu, Yong, et al.
Publicado: (2021)

Host Cell Egress and Invasion Induce Marked Relocations of Glycolytic Enzymes in Toxoplasma gondii Tachyzoites
por: Pomel, Sebastien, et al.
Publicado: (2008)

Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress
por: Huynh, My-Hang, et al.
Publicado: (2022)

An endocytic-secretory cycle participates in Toxoplasma gondii in motility
por: Gras, Simon, et al.
Publicado: (2019)

iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress
por: He, Cheng, et al.
Publicado: (2020)

TgICMAP1 Is a Novel Microtubule Binding Protein in Toxoplasma gondii
por: Heaslip, Aoife T., et al.
Publicado: (2009)

TgMORN1 Is a Key Organizer for the Basal Complex of Toxoplasma gondii
por: Heaslip, Aoife T., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_q47g3lkgmi4jtgpvns39ce7moh