Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

Human coronaviruses (HCoV) are respiratory pathogens that may be associated with the development of neurological diseases, in view of their neuroinvasive and neurotropic properties. The viral spike (S) glycoprotein is a major virulence factor for several coronavirus species, including the OC43 strai...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Coupanec, Alain, Desforges, Marc, Meessen-Pinard, Mathieu, Dubé, Mathieu, Day, Robert, Seidah, Nabil G., Talbot, Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636366/
https://www.ncbi.nlm.nih.gov/pubmed/26545254
http://dx.doi.org/10.1371/journal.ppat.1005261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636366/
https://www.ncbi.nlm.nih.gov/pubmed/26545254
http://dx.doi.org/10.1371/journal.ppat.1005261

Ejemplares similares