Suberoylanilide hydroxamic acid suppresses hepatic stellate cells activation by HMGB1 dependent reduction of NF-κB1

Hepatic stellate cells (HSCs) activation is essential to the pathogenesis of liver fibrosis. Exploring drugs targeting HSC activation is a promising anti-fibrotic strategy. In the present study, we found suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, prominently suppressed...

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Detalles Bibliográficos
Autores principales: Wang, Wenwen, Yan, Min, Ji, Qiuhong, Lu, Jinbiao, Ji, Yuhua, Ji, Juling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636417/
https://www.ncbi.nlm.nih.gov/pubmed/26557438
http://dx.doi.org/10.7717/peerj.1362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636417/
https://www.ncbi.nlm.nih.gov/pubmed/26557438
http://dx.doi.org/10.7717/peerj.1362

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