Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1

The soluble vascular endothelial growth factor (VEGF) receptor 1 (sFLT1) has been tested in both animals and humans for anti-angiogenic therapies, e.g., age-related macular degeneration. We hypothesized that adeno-associated viral vector (AAV)-mediated sFLT1 expression could be used to inhibit abnor...

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Detalles Bibliográficos
Autores principales: Shen, Fanxia, Mao, Lei, Zhu, Wan, Lawton, Michael T., Pechan, Peter, Colosi, Peter, Wu, Zhijian, Scaria, Abraham, Su, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636448/
https://www.ncbi.nlm.nih.gov/pubmed/26090874
http://dx.doi.org/10.1038/gt.2015.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636448/
https://www.ncbi.nlm.nih.gov/pubmed/26090874
http://dx.doi.org/10.1038/gt.2015.57

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