Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells

BACKGROUND: Hypoxia inducible factor-1 alpha (HIF-1α) is thought to play a role in melanoma carcinogenesis. Posttranslational regulation of HIF-1α is dependent on Prolyl hydroxylase (PHD 1–3) and Factor Inhibiting HIF (FIH) hydroxylase enzymes, which require ascorbic acid as a co-factor for optimal...

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Detalles Bibliográficos
Autores principales: Miles, Sarah L., Fischer, Adam P., Joshi, Sandeep J., Niles, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636772/
https://www.ncbi.nlm.nih.gov/pubmed/26547841
http://dx.doi.org/10.1186/s12885-015-1878-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636772/
https://www.ncbi.nlm.nih.gov/pubmed/26547841
http://dx.doi.org/10.1186/s12885-015-1878-5

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