SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positiv...

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Detalles Bibliográficos
Autores principales: Ao, Qilin, Su, Wenjing, Guo, Shuang, Cai, Lei, Huang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637857/
https://www.ncbi.nlm.nih.gov/pubmed/26548925
http://dx.doi.org/10.1038/srep16396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637857/
https://www.ncbi.nlm.nih.gov/pubmed/26548925
http://dx.doi.org/10.1038/srep16396

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