SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positiv...

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Autores principales: Ao, Qilin, Su, Wenjing, Guo, Shuang, Cai, Lei, Huang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637857/
https://www.ncbi.nlm.nih.gov/pubmed/26548925
http://dx.doi.org/10.1038/srep16396
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author Ao, Qilin
Su, Wenjing
Guo, Shuang
Cai, Lei
Huang, Lei
author_facet Ao, Qilin
Su, Wenjing
Guo, Shuang
Cai, Lei
Huang, Lei
author_sort Ao, Qilin
collection PubMed
description Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.
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spelling pubmed-46378572015-11-30 SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α Ao, Qilin Su, Wenjing Guo, Shuang Cai, Lei Huang, Lei Sci Rep Article Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy. Nature Publishing Group 2015-11-09 /pmc/articles/PMC4637857/ /pubmed/26548925 http://dx.doi.org/10.1038/srep16396 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ao, Qilin
Su, Wenjing
Guo, Shuang
Cai, Lei
Huang, Lei
SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title_full SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title_fullStr SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title_full_unstemmed SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title_short SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
title_sort senp1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating hif-1α
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637857/
https://www.ncbi.nlm.nih.gov/pubmed/26548925
http://dx.doi.org/10.1038/srep16396
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