TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

Transforming growth factor-β (TGF-β) signaling plays a key role in progression and metastasis of HCC. This study was undertaken to gain the proof of concept of a small-molecule inhibitor of TGF-β type I receptor kinase, EW-7197 as a potent anti-cancer therapy for HCC. We identified tissue inhibitors...

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Detalles Bibliográficos
Autores principales: Park, Sang-A, Kim, Min-Jin, Park, So-Yeon, Kim, Jung-Shin, Lim, Woosung, Nam, Jeong-Seok, Yhong Sheen, Yhun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637930/
https://www.ncbi.nlm.nih.gov/pubmed/26549110
http://dx.doi.org/10.1038/srep16492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637930/
https://www.ncbi.nlm.nih.gov/pubmed/26549110
http://dx.doi.org/10.1038/srep16492

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