Structural insights into μ-opioid receptor activation

Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To understand the structural basis for μOR activation, we obtained a 2.1 Å X-ray crystal structure of the μOR bound to the morphinan agonist BU72 and stabilized by a G protein-mimetic camelid-...

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Detalles Bibliográficos
Autores principales: Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, A. J., Laeremans, Toon, Feinberg, Evan N., Sanborn, Adrian L., Kato, Hideaki E., Livingston, Kathryn E., Thorsen, Thor S., Kling, Ralf, Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M., Traynor, John R., Weis, William I., Steyaert, Jan, Dror, Ron O., Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639397/
https://www.ncbi.nlm.nih.gov/pubmed/26245379
http://dx.doi.org/10.1038/nature14886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639397/
https://www.ncbi.nlm.nih.gov/pubmed/26245379
http://dx.doi.org/10.1038/nature14886

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