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Enhanced bioavailability of nerve growth factor with phytantriol lipid-based crystalline nanoparticles in cochlea
PURPOSE: Supplementation of exogenous nerve growth factor (NGF) into the cochlea of deafened animals rescues spiral ganglion cells from degeneration. However, a safe and potent delivery of therapeutic proteins, such as NGF, to spiral ganglion cells remains one of the greatest challenges. This study...
Autores principales: | Bu, Meng, Tang, Jingling, Wei, Yinghui, Sun, Yanhui, Wang, Xinyu, Wu, Linhua, Liu, Hongzhuo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639561/ https://www.ncbi.nlm.nih.gov/pubmed/26604754 http://dx.doi.org/10.2147/IJN.S82944 |
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