Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release of ATP is associated with immunogenic cancer cell death as well as inflammatory responses caused by necrotic cell death at sites of trauma or ischemia-reperfusion injury. Using an FDA-approved anti-parasitic a...

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Detalles Bibliográficos
Autores principales: Draganov, Dobrin, Gopalakrishna-Pillai, Sailesh, Chen, Yun-Ru, Zuckerman, Neta, Moeller, Sara, Wang, Carrie, Ann, David, Lee, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639773/
https://www.ncbi.nlm.nih.gov/pubmed/26552848
http://dx.doi.org/10.1038/srep16222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639773/
https://www.ncbi.nlm.nih.gov/pubmed/26552848
http://dx.doi.org/10.1038/srep16222

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