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Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels
Synaptic plasticity requires remodeling of the actin cytoskeleton. Although two actin isoforms, β- and γ-actin, are expressed in dendritic spines, the specific contribution of γ-actin in the expression of synaptic plasticity is unknown. We show that synaptic γ-actin levels are regulated by the E3 ub...
Autores principales: | Schreiber, Joerg, Végh, Marlene J., Dawitz, Julia, Kroon, Tim, Loos, Maarten, Labonté, Dorthe, Li, Ka Wan, Van Nierop, Pim, Van Diepen, Michiel T., De Zeeuw, Chris I., Kneussel, Matthias, Meredith, Rhiannon M., Smit, August B., Van Kesteren, Ronald E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639863/ https://www.ncbi.nlm.nih.gov/pubmed/26527743 http://dx.doi.org/10.1083/jcb.201506048 |
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