Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

Monocytes promote the early host response to infection releasing key pro-inflammatory cytokines, such as IL-1β. The biologically inactive IL-1β precursor is processed to active form by inflammasomes, multi-protein complexes activating caspase-1. Human monocytes exhibit an unconventional one-step pat...

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Detalles Bibliográficos
Autores principales: Viganò, Elena, Diamond, Catherine Emma, Spreafico, Roberto, Balachander, Akhila, Sobota, Radoslaw M., Mortellaro, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640152/
https://www.ncbi.nlm.nih.gov/pubmed/26508369
http://dx.doi.org/10.1038/ncomms9761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640152/
https://www.ncbi.nlm.nih.gov/pubmed/26508369
http://dx.doi.org/10.1038/ncomms9761

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