Cargando…

The PDK1–Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning

Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established in the first few days of life from proliferating local precursors, but the regulating signaling pathways are not fully understood. We found...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zaru, Rossana, Matthews, Stephen P., Edgar, Alexander J., Prescott, Alan R., Gomez-Nicola, Diego, Hanauer, André, Watts, Colin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2015
Materias:	Immune System Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640173/ https://www.ncbi.nlm.nih.gov/pubmed/26401001 http://dx.doi.org/10.4049/jimmunol.1501520

Ejemplares similares

Structural and Functional Basis for p38-MK2-Activated Rsk Signaling in Toll-Like Receptor-Stimulated Dendritic Cells
por: Zaru, Rossana, et al.
Publicado: (2014)

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870
por: Edgar, Alexander J., et al.
Publicado: (2014)

Adaptive from Innate: Human IFN-γ(+)CD4(+) T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults
por: Das, Abhishek, et al.
Publicado: (2017)

The Transcription Factor E4BP4 Is Not Required for Extramedullary Pathways of NK Cell Development
por: Crotta, Stefania, et al.
Publicado: (2014)

An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells
por: White, Andrea J., et al.
Publicado: (2014)

Differential Requirement for CCR4 and CCR7 during the Development of Innate and Adaptive αβT Cells in the Adult Thymus
por: Cowan, Jennifer E., et al.
Publicado: (2014)

Themis2 Is Not Required for B Cell Development, Activation, and Antibody Responses
por: Hartweger, Harald, et al.
Publicado: (2014)

Osteoprotegerin-Mediated Homeostasis of Rank(+) Thymic Epithelial Cells Does Not Limit Foxp3(+) Regulatory T Cell Development
por: McCarthy, Nicholas I., et al.
Publicado: (2015)

A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep
por: Pridans, Clare, et al.
Publicado: (2016)

Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus
por: Lucas, Beth, et al.
Publicado: (2016)

Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus
por: Cosway, Emilie J., et al.
Publicado: (2018)

ERK Signaling Controls Innate-like CD8(+) T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors
por: Maurice, Diane, et al.
Publicado: (2018)

Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus
por: Pridans, Clare, et al.
Publicado: (2018)

SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors
por: Pfeifer, Matthias, et al.
Publicado: (2019)

APRIL Drives a Coordinated but Diverse Response as a Foundation for Plasma Cell Longevity
por: Stephenson, Sophie, et al.
Publicado: (2022)

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk
por: White, Andrea J., et al.
Publicado: (2023)

The effect of the sympathetic nervous system on splenic natural killer cell activity in mice administered the Lactobacillus pentosus strain S-PT84
por: Izumo, Takayuki, et al.
Publicado: (2013)

p90Rsk is not involved in cytostatic factor arrest in mouse oocytes
por: Dumont, Julien, et al.
Publicado: (2005)

RSK2 Is a Modulator of Craniofacial Development
por: Laugel-Haushalter, Virginie, et al.
Publicado: (2014)

Pattern recognition receptor-mediated cytokine response in infants across 4 continents(⋆)()
por: Smolen, Kinga K., et al.
Publicado: (2014)

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study
por: Coulter, Tanya I., et al.
Publicado: (2017)

Lymphocyte subsets in healthy Malawians: Implications for immunologic assessment of HIV infection in Africa
por: Mandala, Wilson L., et al.
Publicado: (2010)

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
por: Lang, Philipp A., et al.
Publicado: (2013)

B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome
por: Castiello, Maria Carmina, et al.
Publicado: (2015)

Effects of maternal geohelminth infections on allergy in early childhood
por: Cooper, Philip J., et al.
Publicado: (2016)

An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex
por: Kracker, Sven, et al.
Publicado: (2015)

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding
por: Cetica, Valentina, et al.
Publicado: (2015)

Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry
por: Cetica, Valentina, et al.
Publicado: (2016)

Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells
por: Chen, Hannah H., et al.
Publicado: (2017)

Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency()
por: Hassan, Amel, et al.
Publicado: (2014)

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin
por: Stier, Matthew T., et al.
Publicado: (2016)

GAS6‐expressing and self‐sustaining cancer cells in 3D spheroids activate the PDK‐RSK‐mTOR pathway for survival and drug resistance
por: Baumann, Christine, et al.
Publicado: (2017)

Identification of differentially expressed genes and the role of PDK4 in CD14(+) monocytes of coronary artery disease
por: Du, Pei, et al.
Publicado: (2021)

Maintenance of CD8(+) memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation
por: Siracusa, Francesco, et al.
Publicado: (2017)

Rsk2 Knockdown in PC12 Cells Results in Sp1 Dependent Increased Expression of the Gria2 Gene, Encoding the AMPA Receptor Subunit GluR2
por: Mehmood, Tahir, et al.
Publicado: (2013)

Okay to Stay? A new plan to help people with long-term conditions remain in their own homes
por: Chapman, Helen, et al.
Publicado: (2018)

RSK Isoforms in Acute Myeloid Leukemia
por: Youn, Minyoung, et al.
Publicado: (2021)

Disseminated intravascular coagulation and its immune mechanisms
por: Popescu, Narcis I., et al.
Publicado: (2022)

IL‐33 delivery induces serous cavity macrophage proliferation independent of interleukin‐4 receptor alpha
por: Jackson‐Jones, Lucy H., et al.
Publicado: (2016)

rSK1 in Rat Neurons: A Controller of Membrane rSK2?
por: Autuori, Eleonora, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ttearf9t1ufacr9h6s9lqf0m8e