Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia

The low density lipoprotein receptor-related protein-5 (LRP5), a co-receptor in the Wnt signaling pathway, modulates bone mass in humans and in mice. Lrp5 knock-out mice have severely impaired responsiveness to mechanical stimulation whereas Lrp5 gain-of-function knock-in and transgenic mice have en...

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Detalles Bibliográficos
Autores principales: Niziolek, Paul J., Bullock, Whitney, Warman, Matthew L., Robling, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640505/
https://www.ncbi.nlm.nih.gov/pubmed/26554834
http://dx.doi.org/10.1371/journal.pone.0140775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640505/
https://www.ncbi.nlm.nih.gov/pubmed/26554834
http://dx.doi.org/10.1371/journal.pone.0140775

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