Non-canonical Activation of Akt in Serum-Stimulated Fibroblasts, Revealed by Comparative Modeling of Pathway Dynamics

The dynamic behaviors of signaling pathways can provide clues to pathway mechanisms. In cancer cells, excessive phosphorylation and activation of the Akt pathway is responsible for cell survival advantages. In normal cells, serum stimulation causes brief peaks of extremely high Akt phosphorylation b...

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Detalles Bibliográficos
Autores principales: Nim, Tri Hieu, Luo, Le, White, Jacob K., Clément, Marie-Véronique, Tucker-Kellogg, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640559/
https://www.ncbi.nlm.nih.gov/pubmed/26554359
http://dx.doi.org/10.1371/journal.pcbi.1004505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640559/
https://www.ncbi.nlm.nih.gov/pubmed/26554359
http://dx.doi.org/10.1371/journal.pcbi.1004505

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