The PTEN pathway in T(regs) is a critical driver of the suppressive tumor microenvironment

The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (T(reg)) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. PTEN acted to stabilize...

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Detalles Bibliográficos
Autores principales: Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640592/
https://www.ncbi.nlm.nih.gov/pubmed/26601142
http://dx.doi.org/10.1126/sciadv.1500845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640592/
https://www.ncbi.nlm.nih.gov/pubmed/26601142
http://dx.doi.org/10.1126/sciadv.1500845

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