PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors

Inhibition of Dll4 (delta-like ligand 4)–Notch signaling–mediated tumor angiogenesis is an attractive approach in cancer therapy. However, inhibition of Dll4-Notch signaling has produced different effects in various tumors, and no biomarkers are available for predicting the anti–Dll4-Notch–associate...

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Detalles Bibliográficos
Autores principales: Iwamoto, Hideki, Zhang, Yin, Seki, Takahiro, Yang, Yunlong, Nakamura, Masaki, Wang, Jian, Yang, Xiaojuan, Torimura, Takuji, Cao, Yihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640632/
https://www.ncbi.nlm.nih.gov/pubmed/26601163
http://dx.doi.org/10.1126/sciadv.1400244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640632/
https://www.ncbi.nlm.nih.gov/pubmed/26601163
http://dx.doi.org/10.1126/sciadv.1400244

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