Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required. We introduce a novel screening system for drug-induced arrhythmogenic risk that combines in vitro pharmacological assays and a multiscale heart simulator. For 12 drugs reported to have varying cardiotox...

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Detalles Bibliográficos
Autores principales: Okada, Jun-ichi, Yoshinaga, Takashi, Kurokawa, Junko, Washio, Takumi, Furukawa, Tetsushi, Sawada, Kohei, Sugiura, Seiryo, Hisada, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640654/
https://www.ncbi.nlm.nih.gov/pubmed/26601174
http://dx.doi.org/10.1126/sciadv.1400142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640654/
https://www.ncbi.nlm.nih.gov/pubmed/26601174
http://dx.doi.org/10.1126/sciadv.1400142

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