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Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coli
Type I modular polyketide synthases are responsible for potent therapeutic compounds that include avermectin (antihelinthic), rapamycin (immunosuppressant), pikromycin (antibiotic), and erythromycin (antibiotic). However, compound access and biosynthetic manipulation are often complicated by propert...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640655/ https://www.ncbi.nlm.nih.gov/pubmed/26601183 http://dx.doi.org/10.1126/sciadv.1500077 |